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VEGF [VG76e]

VEGF [VG76e]

Item no.	20-272-191991
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Culture Cytokines Adenocarcinoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Applications	WB, IP, IHC, ELISA
Clone	VG76e
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-7D2F87
Similar products	20-272-191991
Available
Genway ID:	GWB-7D2F87
Clone:	VG76e
Isotype:	IgG1
Immunogen:	Full length Human VEGF189 expressed in E. coli
Antigen Species:	Human
Target:	VEGF
Localization:	Secreted
Concentration:	1. 3 mg/ml Storage
Buffer:	Phosphate buffered saline
Application Note:	Good results have been reported on human bovine and porcine paraffin sections but only after microwave treatment and using Tris HCl pH 10 buffer (NOT citrate buffer). VEGF-A is a hetero dimer consisting of 2 chains of approximately 24kDa each. Cellular
Localization:	Secreted Myeloma: NS1 VEGF (Vascular Endothelial Growth Factor) in serum is a prognostic indicator of the presence of cancer.
Function:	Growth factor active in angiogenesis vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation promotes cell migration inhibits apoptosis and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
Subunit:	Homodimer; disulfide-linked. Also found as heterodimer with PlGF (By similarity).
Subcellular Location:	Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic has heparin-binding properties and although a signicant proportion remains cell-associated most is freely secreted. VEGF189 is very basic it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix although it may be released as a soluble form by heparin heparinase or plasmin.
Tissue Specificity:	The VEGF189 VEGF-165 and VEGF-121 isoforms are widely expressed whereas the VEGF206 and VEGF-145 are uncommon.
Induction:	Regulated by growth factors cytokines gonadotropins nitric oxide hypoxia hypoglycemia and oncogenic mutations.
Similarity:	Belongs to the PDGF/VEGF growth factor family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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