PI 3 Kinase p85 beta [T4]

T4

Baculovirus expressed (recombinant) Bovine p85 beta subunit of PI 3 Kinase.

T4 is specific for the p85 beta subunit of bovine PI 3 kinase.

0. 1% Sodium Azide; Constituents: 5-10% Foetal Calf Serum 0. 2M Tris HCl. pH 7. 4

1/50 - 1/100Myeloma: NS1 Protein kinases are enzymes that transfer a phosphate group from a phosphate donor generally the g phosphate of ATP onto an acceptor amino acid in a substrate protein. By this basic mechanism protein kinases mediate most of the signal transduction in eukaryotic cells regulating cellular metabolism transcription cell cycle progression cytoskeletal rearrangement and cell movement apoptosis and differentiation. With more than 500 gene products the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.