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GPBB [10D12]

GPBB [10D12]

Item no.	20-272-192142
Manufacturer	GENWAY
Amount	0,1 mg
Type	Antibody
Applications	WB
Clone	10D12
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-90478C
Similar products	20-272-192142
Available
Genway ID:	GWB-90478C
Clone:	10D12
Isotype:	IgG1
Immunogen:	Full length protein (Human).
Antigen Species:	Human
Specificity:	This product reacts with BB and MM isoenzyme.
Target:	GPBB
Localization:	Plasma membrane
Concentration:	2 mg/ml
Purification Note:	Purified by chromatography on protein A Sepharose. Purity is tested by electrophoresis. Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS
Application Note:	AP: Use at an assay dependent dilution. IA: Use at an assay dependent dilution. It is recommended to use three-step assay since signal is low in one-step and two-step assays. WB: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Plasma membrane Myeloma: Sp2/0 GPBB is a sensitive marker for the AMI diagnosis within 4 hours after the onset of chest pain. It has been also shown that GPBB increased in a considerable proportion of AMI patients within 2-3 hours from chest pain onset. GPBB increased early in patients with unstable angina. GPBB can be also a sensitive marker for the detection of peri-operative myocardial ischaemia and infraction in patients undergoing coronary artery bypass grafting.
Function:	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However all known phosphorylases share catalytic and structural properties.
Catalytic Activity:	(1 4-alpha-D-glucosyl)(n) + phosphate = (1 4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. Cofactor: Pyridoxal phosphate.
Enzyme Regulation:	Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates whereas ATP ADP and glucose-6-phosphate allosterically inhibit phosphorylase B.
Subunit:	Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Ptm:	Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Similarity:	Belongs to the glycogen phosphorylase family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,1 mg

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Delivery expected until 8/28/2025

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