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GH1 [GhB9]

GH1 [GhB9]

Item no.	20-272-192282
Manufacturer	GENWAY
Amount	0.5 mg
Category	Oncology Antibodies ELISA Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	ELISA
Clone	GhB9
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-750289
Similar products	20-272-192282
Available
Genway ID:	GWB-750289
Clone:	GhB9
Isotype:	IgG1
Immunogen:	Recombinant full length protein (Human).
Antigen Species:	Human
Specificity:	Reacts with recombinant and natural human growth hormone. There is no cross-reactivity with HPRL FSH LH and insulin.
Target:	GH1
Localization:	Secreted
Concentration:	6 mg/ml
Purification Note:	Purity tested by electrophoresis. Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 4
Application Note:	ELISA: Use at an assay dependent dilution. THis product can be used in an ELISA pair with 20-272-192281 (capture). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted Myeloma: x63-Ag8. 653 Human grwoth hormone (hGH) plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Function:	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subunit:	Monomer dimer trimer tetramer and pentamer disulfide-linked or non-covalently associated in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.
Subcellular Location:	Secreted.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which causes short stature.
Disease:	Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type II (IGHD II) [MIM:173100]. IGHD II is an autosomal dominant deficiency of GH which causes short stature.
Disease:	Defects in GH1 may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth. Pharmaceutical: Available under the names Nutropin or Protropin (Genentech) Norditropin (Novo Nordisk) Genotropin (Pharmacia Upjohn) Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner\' s syndrome.
Miscellaneous:	Circulating GH shows a great heterogeneity due to alternative splicing differential post-translational modifications of monomeric forms oligomerization optional binding to 2 different GH-binding proteins and potentially proteolytic processing.
Similarity:	Belongs to the somatotropin/prolactin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

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Delivery expected until 11/27/2025

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