pS2 [pS2.1]

pS2. 1

Synthetic peptide - corresponding to amino acids 54-84 of Human pS2

Normal stomach or breast carcinoma tissue sections

Cytoplasmic

10mM PBS pH7. 4 0. 2%BSA 0. 09% sodium azide

Cytoplasmic pS2 is a cysteine-rich 6. 5 kDa protein found in both estrogen-dependent (breast tumors) and estrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. pS2 is primarily expressed in estrogen receptor-positive breast tumors and is reportedly useful in identifying a subset of estrogen-dependent breast tumors which may respond to endocrine therapy.

Heterodimer with GKN2; disulfide linked.

Found in stomach with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum small submucosal glands in the esophagus mucous acini of the sublingual gland submucosal glands of the trachea and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract but lower expression found in gastric cancer (at protein level).

Contains 1 P-type (trefoil) domain.