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CD11a [MEM-83]

CD11a [MEM-83]

Item no.	20-272-192557
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Primary Antibodies By Organ Bone Cancer
Type	Antibody
Clone	MEM-83
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-ECAB97
Similar products	20-272-192557
Available
Genway ID:	GWB-ECAB97
Clone:	MEM-83
Isotype:	IgG1
Immunogen:	Tissue / cell preparation (Human). Peripheral blood lymphocytes.
Antigen Species:	Human
Specificity:	The antibody recognizes an unique epitope on CD11a antigen (LFA-1 alpha chain) implicated in activation of LFA-1 complex.
Target:	CD11a
Localization:	Cell Membrane and Plasma membrane
Concentration:	1 mg/ml
Purification Note:	Purified from ascites by protein A affinity chromatography. Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	FACS: Use at an assay dependant concentration. FuncS: Use at an assay dependant concentration. Induces high-affinity conformation of LFA-1. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane and Plasma membrane CD11a is a glycoprotein with a molecular weight of 26 kDa expressed in combination with the CD18 beta chain. The complex is a member of the beta2 integrin family. These molecules function in cell adhesion and specifically bind to CD54 ICAM-2 ICAM-3. CD11a is expressed on lymphocytes granulocytes monocytes and macrophages and is upregulated on activated T-cells. Anti-CD11a from I21/7 reacts with 97% of thymocytes 95% of blood lymphocytes 70% of bone marrow cells of all mouse strains tested.
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction cytotoxic T-cell mediated killing and antibody dependent killing by granulocytes and monocytes.
Subunit:	Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Leukocytes.
Domain:	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.
Similarity:	Contains 1 VWFA domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/13/2025

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