beta Actin [AC-15]

GWB-506CCE

IgG1

Xenopus

Cultured human or chicken fibroblasts as described in Liao et alMolecular weight of beta actin is 42Kd

Cytoplasmic

Ascitic fluid containing 15mM sodium azide

Cytoplasmic Beta actin is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility structure and integrity.

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Component of the BAF complex which includes at least actin (ACTB) ARID1A ARID1B/BAF250 SMARCA2 SMARCA4/BRG1 ACTL6A/BAF53 ACTL6B/BAF53B SMARCE1/BAF57 SMARCC1/BAF155 SMARCC2/BAF170 SMARCB1/SNF5/INI1 and one or more of SMARCD1/BAF60A SMARCD2/BAF60B or SMARCD3/BAF60C. In muscle cells the BAF complex also contains DPF3. Found in a complex with XPO6 Ran ACTB and PFN1. Component of a complex composed at least of ACTB AP2M1 AP2A1 AP2A2 MEGF10 and VIM. Interacts with XPO6.

Defects in ACTB are a cause of juvenile-onset dystonia [MIM:607371]. Dystonia is a movement disorder with a neurological basis due to disordered tonicity of muscle. It is characterized by sustained involuntary muscle contractions that cause abnormal postures and repetitive movements. It may affect muscles throughout the body (generalized) in certain parts of the body (segmental) or may be confined to particular muscles or muscle groups (focal). Individuals with juvenile-onset dystonia due to ACTB mutations present a complicated phenotype that includes progressive generalized dopa-unresponsive dystonia developmental malformations and sensory hearing loss.

Belongs to the actin family.