Collagen III [FH-7A]

FH-7A

Human collagen type III

The antibody specifically recognizes native and denatured collagen type III. It does not recognise collagen types I II IV V VI and X.

Collagen III

raw ascites Storage

For IHC-Fr: Use at a dilution of 1:4 000. WB: 1/100 - 1/1000. The antibody recognizes a ~ 70 kDa band in reduced denatured preps and a ~ 300 kDa band in non-reduced non-denatured preps. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Cellular

Collagen type III occurs in most soft connective tissues along with type I collagen.

Secreted extracellular space extracellular matrix (By similarity).

O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome characteristic facial features (acrogeria) in most patients and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.

Belongs to the fibrillar collagen family.