IL2-R alpha [IL2R.1]

IL2R. 1

BALB/C mice were injected with recombinant human interleukin-2 receptor.

This antibody is specific to a 55 kDa protein known as interleukin 2-receptor (IL-2R alpha). IL-2R alpha is over expressed on the surface of activated T cell HTLV-1 or HTLV-2 positive T cell lines and moderately expressed on activated B cells NK-cells and macrophages.

IL2-R alpha

Phosphate-buffered saline pH 7. 2 containing 1% BSA and 0. 09% sodium azide

Cell Membrane The interleukin 2 receptor alpha (IL2RA) and beta (IL2RB) chains together with the common gamma chain (IL2RG) constitute the high affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low affinity receptor while homodimeric beta (IL2RB) chains produce a medium affinity receptor. Normally an integral membrane protein soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately spliced IL2RA mRNAs have been isolated but the significance of each is presently unknown.

Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer an intermediate affinity monomer (beta chain) and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.

Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].