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PR3 [MCPR3-2]

PR3 [MCPR3-2]

Item no.	20-272-193495
Manufacturer	GENWAY
Amount	0.5 ml
Category	Antibodies Western Blot Immunofluorescence Primary Antibodies
Type	Antibody
Applications	WB, IF
Clone	MCPR3-2
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-A3BF3D
Similar products	20-272-193495
Available
Genway ID:	GWB-A3BF3D
Clone:	MCPR3-2
Isotype:	IgG1Light chain: kappa
Immunogen:	HMC-1/PR3 Cell Granule Extract
Positive Control:	HMC-1/PR3-S176A Cells
Target:	PR3
Concentration:	0. 2 mg/ml Storage
Buffer:	10mM Phosphate-buffered saline pH 7. 4 containing 0. 2% BSA and 0. 1% sodium azide
Application Note:	For IF: Use at a dilution of 1:10. For WB (non-reducing): Use at a dilution of 1:50-1:100 overnight at 4º C. Recommend using fresh lysate for best results. Not tested in other applications. Optimal dilutions should be determined by the researcher. Proteinase 3 (PR3) a constituent of azurophil granules of neutrophils (polymorphonuclear cells PMNs) is the target antigen for most anti-neutrophil cytoplasmic antibodies (c-ANCA) in Wegener\' s Granulomatosis (WG).
Function:	Polymorphonuclear leukocyte serine protease that degrades elastin fibronectin laminin vitronectin and collagen types I III and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
Catalytic Activity:	Hydrolysis of proteins including elastin by preferential cleavage: -Ala-\|-Xaa- & gt; -Val-\|-Xaa-.
Similarity:	Belongs to the peptidase S1 family. Elastase subfamily [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 ml

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Delivery expected until 9/25/2025

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