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AAT [1102]

AAT [1102]

Item no.	20-272-193569
Manufacturer	GENWAY
Amount	5 ml
Category	Antibodies Immunohistochemistry Primary Antibodies
Type	Antibody
Applications	IHC
Clone	1102
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-39A20C
Similar products	20-272-193569
Available
Genway ID:	GWB-39A20C
Clone:	1102
Isotype:	IgG2a
Immunogen:	Purified human Alpha-1-Antitrypsin.
Antigen Species:	Human
Specificity:	This antibody reacts with the 51 kD human alpha-1-antitrypsin. It does not cross-react with alpha-1-acid glycoprotein serum albumin or other serum proteins
Target:	AAT
Concentration:	Lot specific and is stated on the vial Storage
Buffer:	Phosphate-buffered saline pH 7. 2 containing 0. 02% BSA and 0. 09% sodium azide.
Application Note:	This antibody is prediluted for Immunohistochemistry use. The prediluted antibody can be used on frozen cryostat sections as well as formalin-fixed paraffin-embedded tissue sections. For paraffin-embedded tissue sections we recommend an incubation time and temperature of 30 minutes at 37C for this antibody when used in conjunction with our immunoperoxidase staining kit. *Prolonged fixation in buffered formalin can destroy the epitope. Monoclonal Mouse Anti-Human Alpha-1-Antitrypsin
Function:	Inhibitor of serine proteases. Its primary target is elastase but it also has a moderate affinity for plasmin and thrombin.
Subcellular Location:	Secreted.
Domain:	The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.
Miscellaneous:	Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.
Similarity:	Belongs to the serpin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 ml

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Delivery expected until 8/28/2025

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