« Back
Home /
CD4 [YTS191.1] (FITC)

CD4 [YTS191.1] (FITC)

Item no.	20-272-193770
Manufacturer	GENWAY
Amount	0.1 mg
Category	Antibodies Primary Antibodies
Type	Antibody
Clone	YTS191. 1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-82DEBF
Similar products	20-272-193770
Available
Genway ID:	GWB-82DEBF
Clone:	YTS191. 1
Isotype:	IgG2b
Antigen Species:	Mouse
Specificity:	Mouse CD4
Target:	CD4
Conjugation:	FITC
Concentration:	0. 1 mg/ml Storage
Buffer:	PBS pH7. 2 containing BSA and 0. 02% sodium azide
Application Note:	For FACS: Use 1µ g for 10^6 cells. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Recognises the murine CD4 cell surface antigen expressed by a subset of T lymphocytes.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.1 mg

available

Delivery expected until 8/28/2025

Express Delivery: Save 1 days

Compare

Add to wishlist

Get an offer