INTERLEUKIN 6

MP5-20F3

IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells it induces myeloma and plasmacytoma growth it induces nerve cells differentiation in hepatocytes it induces acute phase reactants.

Belongs to the IL-6 superfamily. [1] Hayashi M. Shimba S. and Tezuka M. et al. Characterization of the molecular clock in mouse peritoneal macrophages[2] Westberg J. A. Serlachius M. Lankila P. Penkowa M. Hidalgo J. and Andersson L. C. Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling[3] Suzuki M. Sugimoto Y. Ohsaki Y. Ueno M. Kato S. Kitamura Y. Hosokawa H. Davies J. P. Ioannou Y. A. Vanier M. T. Ohno K. and et al. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain[4] Balasubramaniyan V. Murugaiyan G. Shukla R. Bhonde R. R. and Nalini N. Leptin downregulates ethanol-induced secretion of proinflammatory cytokines and growth factor[5] Buchweitz J. P. Harkema J. R. and Kaminski N. E. et al. Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice[6] van Snick J. Cayphas S. Szikora J. -P. Renauld J. -C. van Roost E. Boon T. Simpson R. J. cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. [7] Tanabe O. Akira S. Kamiya T. Wong G. G. Hirano T. Kishimoto T. Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. [8] Chiu C. P. Moulds C. Coffman R. L. Rennick D. Lee F. Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. [9] Grenett H. E. Fuentes N. L. Fuller G. M. Cloning and sequence analysis of the cDNA for murine interleukin-6. [10] Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. et al. The transcriptional landscape of the mammalian genome.