TNF-ALPHA

GWB-F7A2D2

The monoclonal antibody V1q can be used for inhibition of the biological activity. Furthermore the antibody V1q is useful for flow cytometry. Tumor Necrosis Factor alpha (TNF-alpha) is a cytokine which has various immunomodulatory. anti-tumor and toxic effects. TNF-alpha has been detected in various inflammatory status and appears to be a critical mediator in the lethality of septic shock. Furthermore. TNF-alpha has also been found in inflammatory foci such as synovial effusions in rheumatoid arthritis. systemic circulation in septic shock. parasitemia and rejection of renal transplants. The monoclonal antibody V1q reacts with both natural and recombinant TNF-alpha and shows neutralizing activity.

Homotrimer.

The soluble form derives from the membrane form by proteolytic processing.

Belongs to the tumor necrosis factor family. [1] Semon D. Kawashima E. Jongeneel C. V. Shakhov A. N. and Nedospasov S. A. Nucleotide sequence of the murine TNF locus including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes[2] Jongeneel C. V. et al. Direct Submission[3] Shirai T. Shimizu N. Shiojiri S. Horiguchi S. Ito H. Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor. [4] Pennica D. Hayflick J. S. Bringman T. S. Palladino M. A. Goeddel D. V. Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. [5] Caput D. Beutler B. Hartog K. Thayer R. Brown-Shimer S. Cerami A. Identification of a common nucleotide sequence in the 3\' -untranslated region of mRNA molecules specifying inflammatory mediators. [6] Fransen L. Mueller R. Marmenout A. Tavernier J. van der Heyden J. Kawashima E. Chollet A. Tizard R. van Heuverswyn H. van Vliet A. et al. Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. [7] Shakhov A. N. Nedospasov S. A. Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice. [8] Semon D. Kawashima E. Jongeneel C. V. Shakhov A. N. Nedospasov S. A. Nucleotide sequence of the murine TNF locus including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes. [9] Ikegami H. Makino S. Yamato E. Kawaguchi Y. Ueda H. Sakamoto T. Takekawa K. Ogihara T. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. [10] Iraqi F. Teale A. Cloning and sequencing of the Tnfa genes of three inbred mouse strains.