MELANOCYTE ASSOCIATED ANTIGEN

GWB-5C5286

The monoclonal antibody PNL2 can be used for Western blotting. immuno precipitation and immunohistology on frozen and paraffin sections. The monoclonal antibody PNL2 recognises a melanocyte associated antigen. The antigen recognised by PNL2 is chemically resistant and thus allows immunostaining after bleaching or decalcification. PNL2 stains only melanocytic lesions. clear cell sarcoma. melanotic schwannome. angiomyolipoma and lymphangioleiomyomatosis. The antibody PNL2 has the same specificity as anti Melan A and HMB-45 antibodies. However PNL2 staining is stronger and more consistent. The antigen recognised by PNL2 is different from Melan A and gp100. N/AN/A [1] Wagner S. N. Wagner C. Hofler H. Atkinson M. J. and Goos M. et al. Expression cloning of the cDNA encoding a melanoma-associated Ag recognized by mAb HMB-45. Identification as melanocyte-specific Pmel 17 cDNA