THO complex subunit 4

GWB-30DE27

Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay.

Nucleus. Cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.

Contains 1 RRM (RNA recognition motif) domain. [1] Bruhn L. Munnerlyn A. and Grosschedl R. et al. ALY a context-dependent coactivator of LEF-1 and AML-1 is required for TCRalpha enhancer function[2] Bruhn L. Munnerlyn A. and Grosschedl R. et al. Direct Submission[3] Bruhn L. Munnerlyn A. Grosschedl R. ALY a context-dependent coactivator of LEF-1 and AML-1 is required for TCRalpha enhancer function. [4] Stutz F. Bachi A. Doerks T. Braun I. C. Seraphin B. Wilm M. Bork P. Izaurralde E. REF an evolutionarily conserved family of hnRNP-like proteins interacts with TAP/Mex67p and participates in mRNA nuclear export. [5] Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. et al. The transcriptional landscape of the mammalian genome. [6] Lejeune F. Ishigaki Y. Li X. Maquat L. E. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. [7] Perez-Alvarado G. C. Martinez-Yamout M. Allen M. M. Grosschedl R. Dyson H. J. Wright P. E. Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes.