Comparison

Lamin-A/C

Item no. 20-373-85103
Manufacturer GENWAY
Amount 1 ml
Type Antibody
Applications WB, FC, IP, IHC
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-6E9368
Similar products 20-373-85103
Available
Genway ID:
GWB-6E9368
Clone Number:
JOL2
Function:
Lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subcellular Location:
Nucleus.
Tissue Specificity:
Isoform C2 is specifically expressed in germ cells. This specific expression and unique structure suggests a role for this isoform in determining the organization of nuclear and chromosomal structures during spermatogenesis.
Ptm:
Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Ptm:
Isoform C is phosphorylated on Ser-392 Ser-407 and Ser-409 at interphase.
Ptm:
The N-terminus is blocked.
Miscellaneous:
The structural integrity of the lamina is strictly controlled by the cell cycle as seen by the disintegration and formation of the nuclear envelope in prophase and telophase respectively.
Similarity:
Belongs to the intermediate filament family. [1] Nakajima N. and Abe K. et al. Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins[2] Riedel W. and Werner D. et al. Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence[3] Furukawa K. Inagaki H. and Hotta Y. et al. Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice[4] Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. et al. The transcriptional landscape of the mammalian genome[5] Gerhard D. S. Wagner L. Feingold E. A. Shenmen C. M. Grouse L. H. Schuler G. Klein S. L. Old S. Rasooly R. Good P. Guyer M. et al. The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)[6] Nakajima N. Abe K. Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins. [7] Riedel W. Werner D. Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. [8] Furukawa K. Inagaki H. Hotta Y. Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice. [9] Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. et al. The transcriptional landscape of the mammalian genome. [10] Nakajima N. Sado T. Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 ml
Available: In stock
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