sLOX-1

IgG1

Recombinant sLOX-1 expressed in E. coli.

Monoclonal Antibodies to Cardiac Markers

PBS pH 7. 4Applications Notes : Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Receptor that mediates the recognition internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction resulting in pro-inflammatory responses pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release monocyte adhesion and apoptosis. In addition to binding oxLDL it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products activated platelets monocytes apoptotic cells and both Gram-negative and Gram-positive bacteria.

Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.

By inflammatory cytokines such as TNF-alpha IFN-gamma IL-6 and by pathological conditions such as hyperlipidemia hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions by oxLDL reactive oxygen species and fluid shear stress suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction.

The C-type lectin domain mediates the recognition and binding of oxLDL.

N-glycosylated.

Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref. 10 Ref. 13 and Ref. 18) variations in OLR1 modify the risk of AD while according to other (Ref. 15 and Ref. 16) they do not.