CD4

Item no.	20-511-241110
Manufacturer	GENWAY
Amount	1 mg
Category	Oncology Antibodies Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Clone	LT4
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-8F2B12
Similar products	20-511-241110
Available
Genway ID:	GWB-8F2B12
Isotype:	IgG1
Clone:	LT4Host Animal: Mouse. Hybridization of X63. 653 myeloma
Immunogen:	Normal human blood lymphocytes.
Specificity:	Clone LT4 reacts with CD4 antigen (MW 59kDa). LT4 blocks 50% of the binding of MAbs Leu 3a.
Type of Product:	Monoclonal Antibodies to Human CDs
Concentration:	1. 4mg/ml (OD280nm E0. 1% = 1. 4)Preservatives: NaN3
Buffer:	PBS pH 7. 4Applications Notes : Can be used to enumerate T helper/inducer subset in peripheral blood and tissue. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to CD4. Monoclonal Antibody to CD4
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 11/27/2025

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