Adiponectin

IgG2a

Recombinant Human Adiponectin (from E. coli)

Monoclonal Antibodies to Proteins and Bioactive Peptides

PBS pH 7. 4Applications Notes : Suitable for use in Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Important adipokine involved in the control of fat metabolism and insulin sensitivity with direct anti-diabetic anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities depending on the type of complex LMW MMW or HMW.

Secreted.

During hormone-induced adipose differentiation and activated by insulin.

O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

HMW-complex blood contents are higher in females than in males are increased in males by castration and decreased again upon subsequent testosterone treatment which blocks HMW-complex secretion.

Contains 1 collagen-like domain.