CTNNB1 Antibody

GWB-55545F

IgG1 Description: Homo sapiens catenin (cadherin-associated protein) beta 1 88kDa (CTNNB1) transcript variant 1

WB 1:1000 Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers such as those lining organ surfaces. AJs mediate adhesion between cells communicate a signal that neighboring cells are present and anchor the actin cytoskeleton. In serving these roles AJs regulate normal cell growth and behavior. At several stages of embryogenesis wound healing and tumor cell metastasis cells form and leave epithelia. This process which involves the disruption and reestablishment of epithelial cell-cell contacts may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the \' contact inhibition\' signal which instructs cells to stop dividing once an epithelial sheet is complete