PKMYT1 Antibody

GWB-9926A7

IgG2a Description: Homo sapiens protein kinase membrane associated tyrosine/threonine 1 (PKMYT1) transcript variant 1

WB 1:500 IHC 1:50 IF 1:100 Flow 1:100 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2) and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.