Antibodies

CD321

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone BV16
Applications FC, IHC
Amount 0.025 mg
ArtNr 20-783-310312
Available
Genway ID:
GWB-34B222
Specificity:
CD321NCBI
Gene ID:
50848
Isotype:
IgG2b
Clone:
BV16
Immunogen:
Human JAM-Fc fusion protein
Fusion Partner:
Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100mlSuggested
Dilution:
Flow Cytometry - 1/10 - 1/50
Function:
Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1 thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection serves as receptor for the virus.
Subunit:
Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).
Subcellular Location:
Cell junction tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
Ptm:
N-glycosylated.
Similarity:
Belongs to the immunoglobulin superfamily.
Similarity:
Contains 2 Ig-like V-type (immunoglobulin-like) domains. 1. Bazzoni. G. et al. (2000) Interaction of Junctional Adhesion Molecule with the tight junction components ZO-1. cingulin. and occludin.
Amount: 0.025 mg
Available: In stock
Listprice: €212.88
Price: €212.88
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