Manufacturer GENWAY
Type Antibody
Specific against other
Clone HM beta 1-1
Applications FC
Amount 25 TESTS
ArtNr 20-783-310354
Genway ID:
Gene ID:
HM beta 1-1
Purified mouse VLA-4 antigen
Fusion Partner:
Spleen cells from immunised Armenian hamsters were fused with cells of the P3U1 mouse myeloma cell line.
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Flow Cytometry - Neat - 1/5
Integrins alpha-1/beta-1 alpha-2/beta-1 alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1 alpha-3/beta-1 alpha-4/beta-1 alpha-5/beta-1 alpha-8/beta-1 alpha-10/beta-1 alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1 alpha-2/beta-1 alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1 cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions. When associated with alpha-7/beta-1 integrin regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1 serves as a platform for SRC activation or inactivation.
Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1 alpha-2 alpha-3 alpha-4 alpha-5 alpha-6 alpha-7 alpha-8 alpha-9 alpha-10 alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3 when associated with alpha-7 but not with alpha-5. Interacts with FLNA FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells.
Tissue Specificity:
Isoform beta-1A is widely expressed other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin liver skeletal muscle cardiac muscle placenta umbelical vein endothelial cells neuroblastoma cells lymphoma cells hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle kidney liver placenta cervical epithelium umbilical vein endothelial cells fibroblast cells embryonal kidney cells platelets and several blood cell lines. Isoform beta-C-2 rather than isoform beta-1C is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).
The cysteine residues are involved in intrachain disulfide bonds (By similarity).
Belongs to the integrin beta chain family.
Contains 1 VWFA domain. 1. Noto. K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Discount: -10.0%
Price: €191.59
You save: €21.29

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