FOXP1


Manufacturer	GENWAY
Category	Oncology Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	JC12
Applications	WB, IHC
Amount	0.025 mg
Item no.	20-783-310528
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-36314C
Specificity:	FOXP1
Specificity:	FOXP1
Clone:	JC12
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. 1mM EDTA pH8. 0 is recommended for this purpose. Histology: Human Tonsil
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 1/200 - 1/500
Function:	Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development (By similarity).
Subunit:	Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity).
Subcellular Location:	Nucleus (Probable).
Domain:	The leucine-zipper is required for dimerization and transcriptional repression (By similarity).
Disease:	A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9; 3)(p13; p14. 1) with PAX5.
Similarity:	Contains 1 C2H2-type zinc finger.
Similarity:	Contains 1 fork-head DNA-binding domain. 1. Banham. A. H. et al. (2005) Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. 2. Banham. A. H. et al. (2001) The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024