HLA G

HLA G

MEM-G/9

Spleen cells from immunised Balb/c mice were fused with myeloma cells.

Purified IgG prepared by affinity chromatography on Protein A

Belongs to the MHC class I family. Summary: HLA-G belongs to the HLA class I heavy chain paralogues This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide exons 2 and 3 encode the alpha1 and alpha2 domain which both bind the peptide exon 4 encodes the alpha3 domain exon 5 encodes the transmembrane region and exon 6 encodes the cytoplasmic tail. 1. Feurnel. S. et al. (2000) Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules. 2. Menier. C. et al. (2003) Characterization of Monoclonal Antibodies Recognizing HLA-G or HLA-E: New Tools to Analyze the Expression of Nonclassical HLA Class I Molecules.