CD143

GWB-F5387B

CD143

Human lung CD143

This product recognises human CD143 also know as angiotensin - converting enzyme (ACE). CD143 exists in two forms a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles) epithelial cells (especially in proximal renal tubules and small intestine) by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. This antibody recognises active ACE binding to an N-terminal domain epitope different to that recognised by clone i2H5.

Flow Cytometry - Neat 1. Danilov. S. M. et al. (1994) Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of amino-terminal active site. 2. Metzger. R. et al. (2000) CD143 in the development of atherosclerosis. 3. Danilov. S. et al. (1991) Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme.