NEUROFILAMENT

NEUROFILAMENTNCBI

NEUROFILAMENT

Human brain neurofilament

This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Histology: Cerebellum

Immunohistology - Frozen - 1/40Immunohistology - Paraffin - 1/40 Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light medium and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This protein is the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E) disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq].