APOLIPOPROTEIN A1

GWB-D2A325

335

G2

This product recognises Apolipoprotein A-1 (also known as Apo-A1) a lipid-binding protein which enables the transport of dietary lipids for storage metabolism and secretion. Apo-A1 plays an important part in the removal of cholesterol from cells. This product reacts with both free human Apo-A1 and High Density Lipoprotein (HDL) bearing Apo-A1 but does not cross-react with ApoE ApoB or Albumin.

0. 01M Sodium Phosphate0. 01M Sodium Borate0. 15M Sodium Chloride

Western Blotting - 1/2000 - 1/8000 Summary: This protein is apolipoprotein A-I which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This protein is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies including Tangier disease and with systemic non-neuropathic amyloidosis. Summary: This protein is apolipoprotein A-I which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This protein is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies including Tangier disease and with systemic non-neuropathic amyloidosis. [provided by RefSeq].