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CYTOKERATIN

CYTOKERATIN

Item no.	20-783-73187
Manufacturer	GENWAY
Amount	0.5 ml
Category	Oncology Antibodies Cell Biology Cytoskeleton Immunohistochemistry Primary Antibodies Intermediate filaments By Organ Colorectal Cancer
Type	Antibody
Applications	IHC
Clone	Lu-5
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-EC1F81
Similar products	20-783-73187
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Genway ID:	GWB-EC1F81
Specificity:	CYTOKERATIN
Specificity:	CYTOKERATIN
Clone:	Lu-5
Immunogen:	Native
Specificity Note:	With tonsil colon liver and a varirty of normal tissues. Tumoural tissues in the gastrointestinal tract urogenital tract and skin.
Immunohistology:	Use acetone fixed (5 min at 4 degree C) The antigen is also resistant to formaldehyde (1%) fixation and paraffin embedding. For optimal staining paraffin embedded tissues should be predigested with 0. 1% pronase for 10 minutes.
Buffer Solution:	See belowLyophilised from TBS 10% FCS 0. 05% kathon/Luviskol K30 and 1% BSA. Reconstitution: With 500 ul of sterile distilled water. Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 1/150 - 1/750
Function:	Together with KRT19 helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Subunit:	Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19 interacts with DMD. Interacts with TCHP.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Ptm:	Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Disease:	Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
Miscellaneous:	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Similarity:	Belongs to the intermediate filament family. 1. von Overbeck. J. et al. (1985) Immunohistochemical characterization of an anti-epithelial monoclonal antibody (mAB lu-5)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 ml

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