Comparison

CD142

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone CLB/TF-1
Applications FC, ELISA
Amount 0.2 mg
Item no. 20-783-74336
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-8ED346
Specificity:
CD142
Specificity:
CD142
Clone:
CLB/TF-1
Specificity Note:
This product recognises human CD142 a 45kD cell surface glycoprotein which is otherwise known as Tissue Factor (TF). CD142 expression can be induced on monocytes macrophages and endothelial cells by various stimuli including interleukin 1 tumour necrosis factor and endotoxin. CD142 initiates the blood clotting cascade by binding coagulation factor VIIa which activates factor IX or factor X by specific limited proteolysis. CD142 also plays an important role in inflammation angiogenesis and the pathophysiology of atherosclerosis and cancer.
Preparation:
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:
TRIS buffered saline
Preservative Stabilisers:
0. 09%Sodium Azide (NaN3) Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Induction:
TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF as well as by endotoxin to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
Similarity:
Belongs to the tissue factor family. 1. van der Putten. R. F. et al. (2005) High-affinity antibodies in a new immunoassay for plasma tissue factor: reduction in apparent intra-individual variation. 2. Roy. F. M. et al. (2005) State and diagnostic value of plasma tissue factor in early-hospitalised patients with chest pain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.2 mg
Available: In stock
available

Delivery expected until 5/30/2024 

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close