IgA

GWB-3F3C10

IgA

This product recognises monkey IgA and does not cross-react with IgG or IgM. Clone IgA5-3B has been shown to detect secreted IgA in cat saliva and rhesus monkey jejunal washes and This product can be used as a detection reagent in ELISA assays in combination with as a capture reagent.

Phosphate buffered saline pH7. 2

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.

Contains 3 Ig-like (immunoglobulin-like) domains. 1. Beatty. J. A. et al. (1998) Feline immunodeficiency virus (FIV)-associated lymphoma: a potential role for immune dysfunction in tumourigenesis. 2. Grant. C. K. (1995) Purification and characterization of feline IgM and IgA isotypes and three subclasses of IgG. In: Feline immunology and immunodeficiency. Eds. Willett. B. J. and Jarrett. O. Oxford University Press pp. 95-107. 3. Grant. C. K. (1995) Immunoglobulin changes associated with feline immunodeficiency virus infections. In: Feline immunology and immunodeficiency Eds. Willett. B. J. and Jarrett. O. Oxford University Press pp. 170-189.