MEF2

GWB-FAE7C7

BC3H1 cells. BrainCellular

Synthetic peptide corresponding to aa 487-507 of human MEF-2. The myocyte enhancer factors-2 (MEF-2) family of transcription factors associate with a variety of co-repressors or co-activators to regulate development and function of T cells neuronal cells and muscle cells. Four distinct family members arise from alternatively splices transcripts termed MEF-2A MEF-2B MEF-2C and MEF-2D. These members bind as homo-and heterodimers to the MEF2 site in the promoter region of affected genes. Differential regulation in the expression of the 4 transcripts implies functional distinction for each during embryogenesis and development.