Apoptosis Protease Activating Factor-1 (Apaf-1)

GWB-7839A4

Testis

A synthetic peptide derived from the C-terminus of human Apaf-1. Apaf-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (Apaf-2). The resulting Apaf-1/cytochrome c complex associates with the zymogen form of caspase-9 (Apaf-3) in the presence of dATP or ATP promoting the autocatalytic activation of caspase-9. This antibody will be useful in studies of the activation of caspases through Apaf1 and also in metastatic melanomas where Apaf-1 is inactivated which leads to defects in the ezecution of apoptotic cell death.