CD154

GWB-A941F6

Raji cells. TonsilCellular

Synthetic peptide corresponding to aa 51-69 of human CD154. CD154 / CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes but also exists as a soluble form extracellularly. CD40L is the ligand for CD40 a member of the TNF superfamily which is expressed on the cell surface of B cells macrophages/monocytes dendritic cells vascular endothelial cells and epithelial cells. CD40L plays an important role in B cell proliferation antibody class switching modulation of apoptosis in the germinal center through interaction with B cells expressing CD40 and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes.