Occludin

GWB-8063F2

HT29 cells Cellular

Synthetic peptide corresponding to C-terminal of human occludin. Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms ranging up to approximately 82 kDa. This phosphorylation is thought to be involved in regulating both the localization and the function of Occludin. Polyunsaturated fatty acids are known to up-regulate Occludin expression increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue Occludin is highly and continuously expressed at cell-cell contact sites whereas non-neural tissues show lower expression and discontinuous distribution.