Mouse Anti-Mouse CD45.1/Ly-5.1

GWB-66B3CE

A20

Mouse CD 45. 1 (Leukocyte Common Antigen)The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase e. g. CD45 is able to dephosphorylate the Src family of protein kinases. 1 2 This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement cytokine signaling and Fc receptor stimulation. 1 2 The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms such as the restricted variants (CD45R; see companion products 1660 1665 1675 1685 and 1820) and as allelic forms CD45. 1/Ly-5. 1 and CD45. 2/Ly-5. 2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45. 1 and CD45. 2 has been exploited in studies where resolution of donor and recipient cells is essential such as in gene therapy or bone marrow transplantation. 3 4 The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD 45. 1 allotype.

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Membrane; Single-pass type I membrane protein. Developmental Stage: Expression is restricted to the hematopoietic compartment of development.

Heavily N- and O-glycosylated.

Contains 2 fibronectin type-III domains.