GOAT ANTI RAT LEPTIN

LEPTIN

Phosphate buffered saline pH7. 2

Recombinant rat leptin

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. Subcellular locationSecreted Probable. Sequence similaritiesBelongs to the leptin family. [1] \" A second subunit of CD8 is expressed in human T cells. \" Norment A. M. Littman D. R. EMBO J. 7:3433-3439(1988) [PubMed: 3145195] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: T-cell. [2] \" The human Lyt-3 molecule requires CD8 for cell surface expression. \" Disanto J. P. Knowles R. W. Flomenberg N. EMBO J. 7:3465-3470(1988) [PubMed: 3145196] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [3] \" A second chain of human CD8 is expressed on peripheral blood lymphocytes. \" Shiue L. Gorman S. D. Parnes J. R. J. Exp. Med. 168:1993-2005(1988) [PubMed: 3264320] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [4] \" Recent duplication of the two human CD8 beta-chain genes. \" Nakayama K. Kawachi Y. Tokito S. Minami N. Yamamoto R. Imai T. Gachelin G. Nakauchi H. J. Immunol. 148:1919-1927(1992) [PubMed: 1541829] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4). [5] \" Generation and annotation of the DNA sequences of human chromosomes 2 and 4. \" Hillier L. W. Graves T. A. Fulton R. S. Fulton L. A. Pepin K. H. Minx P. Wagner-McPherson C. Layman D. Wylie K. Sekhon M. Becker M. C. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Kremitzki C. Oddy L. Du H. Sun H. Bradshaw-Cordum H. Ali J. Carter J. Cordes M. Harris A. Isak A. van Brunt A. Nguyen C. Du F. Courtney L. Kalicki J. Ozersky P. Abbott S. Armstrong J. Belter E. A. Caruso L. Cedroni M. Cotton M. Davidson T. Desai A. Elliott G. Erb T. Fronick C. Gaige T. Haakenson W. Haglund K. Holmes A. Harkins R. Kim K. Kruchowski S. S. Strong C. M. Grewal N. Goyea E. Hou S. Levy A. Martinka S. Mead K. McLellan M. D. Meyer R. Randall-Maher J. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Shah N. Swearengen-Shahid S. Snider J. Strong J. T. Thompson J. Yoakum M. Leonard S. Pearman C. Trani L. Radionenko M. Waligorski J. E. Wang C. Rock S. M. Tin-Wollam A. -M. Maupin R. Latreille P. Wendl M. C. Yang S. -P. Pohl C. Wallis J. W. Spieth J. Bieri T. A. Berkowicz N. Nelson J. O. Osborne J. Ding L. Meyer R. Sabo A. Shotland Y. Sinha P. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Jones T. A. She X. Ciccarelli F. D. Izaurralde E. Taylor J. Schmutz J. Myers R. M. Cox D. R. Huang X. McPherson J. D. Mardis E. R. Clifton S. W. Warren W. C. Chinwalla A. T. Eddy S. R. Marra M. A. Ovcharenko I. Furey T. S. Miller W. Eichler E. E. Bork P. Suyama M. Torrents D. Waterston R. H. Wilson R. K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]||?|| [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (M C). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). [7] \" Transcriptional diversity at the duplicated human CD8 beta loci. \" DiSanto J. P. Smith D. de Bruin D. Lacy E. Flomenberg N. Eur. J. Immunol. 23:320-326(1993) [PubMed: 8436166] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 162-210 (ISOFORMS 1; 2; 3; 5; 6; 7 AND 8) ALTERNATIVE SPLICING TISSUE SPECIFICITY. Tissue: Peripheral blood.