MOUSE ANTI RAT CD80

CD80

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD80 otherwise known as B7-1 a type I transmembrane glycoprotein and member of the Ig superfamily which acts as a ligand for both CD28 and CD152 (CTLA-4) and is primarily expressed on antigen presenting cells (APCs) including dendritic cells. CD80 is a B cell activation antigen which functions in the CD28-CD80/CD86 co-stimulatory pathway vital for T cell activation and proliferation. In contrast the interaction of CD80 with CD152 has an inhibitory effect on T cell responses. Clone 3H5 has been shown to block the co-stimulatory activity of rat CD80. Recommended for functional studies. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L) 1. Ruan W. J. et al. (2006) IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. J. Zhejiang Univ. Sci. B. 7: 929-932. 2. Pereira R. C. and Canalis E. (1999) Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein 1 expression in cultured osteoblasts. Endocrinol. 140: 1998-2003. [1] \" Identification and characterization of genes differentially expressed in meningiomas. \" Murphy M. Pykett M. J. Harnish P. Zang K. D. George D. L. Cell Growth Differ. 4:715-722(1993) [PubMed: 7694637] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT PHE-11. Tissue: Leptomeninges. [2] \" Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. \" Yamauchi T. Umeda F. Masakado M. Isaji M. Mizushima S. Nawata H. Biochem. J. 303:591-598(1994) [PubMed: 7980422] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [4] NIEHS SNPs programSubmitted (JAN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT PHE-11. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis and Uterus. [6] \" Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. \" Akaogi K. Okabe Y. Funahashi K. Yoshitake Y. Nishikawa K. Yasumitsu H. Umeda M. Miyazaki K. Biochem. Biophys. Res. Commun. 198:1046-1053(1994) [PubMed: 8117260] [Abstract]Cited for: PROTEIN SEQUENCE OF 27-46 FUNCTION. Tissue: Urinary bladder carcinoma. [7] \" Signal peptide prediction based on analysis of experimentally verified cleavage sites. \" Zhang Z. Henzel W. J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]Cited for: PROTEIN SEQUENCE OF 27-41. [8] \" Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. \" Oh Y. Nagalla S. R. Yamanaka Y. Kim H. -S. Wilson E. Rosenfeld R. G. J. Biol. Chem. 271:30322-30325(1996) [PubMed: 8939990] [Abstract]Cited for: PROTEIN SEQUENCE OF 27-36 FUNCTION GLYCOSYLATION. [9] \" Interaction of IGF-binding protein-related protein 1 with a novel protein neuroendocrine differentiation factor results in neuroendocrine differentiation of prostate cancer cells. \" Wilson E. M. Oh Y. Hwa V. Rosenfeld R. G. J. Clin. Endocrinol. Metab. 86:4504-4511(2001) [PubMed: 11549700] [Abstract]Cited for: POSSE INTERACTION WITH CHMP3.