Neurotensin

Pyr-LYENKPRRPYIL

C78H121N21O20

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity).

Belongs to the neurotensin family. [1] Gierl M. S. Karoulias N. Wende H. Strehle M. and Birchmeier C. et al. The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells[2] Fadel J. Dobner P. R. and Deutch A. Y. et al. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice[3] Garlow S. J. Boone E. Kinkead B. and Nemeroff C. B. et al. Genetic analysis of the hypothalamic neurotensin system[4] Shroyer N. F. Wallis D. Venken K. J. Bellen H. J. and Zoghbi H. Y. et al. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation[5] Cui H. Cai F. and Belsham D. D. et al. Anorexigenic hormones leptin insulin and alpha-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models[6] Dobner P. R. Fadel J. Deitemeyer N. Carraway R. E. Deutch A. Y. Neurotensin-deficient mice show altered responses to antipsychotic drugs. [7] Ahn H. -J. Cho J. -J. Mouse proneurotensin/proneuromedin N is induced in mast cell line after IgE cross-linking. [8] Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. et al. The transcriptional landscape of the mammalian genome.