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Elk-1 (Phospho-Ser383) Antibody Blocking Peptide

Elk-1 (Phospho-Ser383) Antibody Blocking Peptide

Item no.	06-785-213004
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Peptides & Proteins Peptides By Organ Lung Cancer
Type	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-2DCA1D
Similar products	06-785-213004
Available
Genway ID:	GWB-2DCA1D
Function:	Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.
Subunit:	Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity.
Subcellular Location:	Nucleus.
Tissue Specificity:	Lung and testis.
Ptm:	Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
Ptm:	On mitogenic stimulation phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.
Similarity:	Belongs to the ETS family.
Similarity:	Contains 1 ETS DNA-binding domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/25/2025

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