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BCL-2 (Phospho-Ser70) Antibody Blocking Peptide

BCL-2 (Phospho-Ser70) Antibody Blocking Peptide

Item no.	06-785-213062
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Peptides & Proteins Cell Biology Cell Status Apoptosis Autophagy Peptides By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-B2BCC1
Similar products	06-785-213062
Available
Genway ID:	GWB-B2BCC1
Function:	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subunit:	Forms homodimers and heterodimers with BAX BAD BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1 RAF-1 TP53BP2 BBC3 BCL2L1 MRPL41 and BNIPL. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets.
Subcellular Location:	Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity:	Expressed in a variety of tissues.
Domain:	The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.
Ptm:	Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Ptm:	Proteolytically cleaved by caspases during apoptosis. The cleaved protein lacking the BH4 motif has pro-apoptotic activity causes the release of cytochrome c into the cytosol promoting further caspase activity.
Disease:	A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14; 18)(q32; q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Similarity:	Belongs to the Bcl-2 family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 8/28/2025

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