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LIMK1 (Phospho-Thr508) Antibody Blocking Peptide

LIMK1 (Phospho-Thr508) Antibody Blocking Peptide

Item no.	06-785-213111
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Peptides & Proteins Peptides By Organ Brain Cancer
Type	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-C652FE
Similar products	06-785-213111
Available
Genway ID:	GWB-C652FE
Function:	Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein.
Subunit:	Self-associates. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with SSH1. Interacts with NISCH (By similarity).
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Ptm:	Autophosphorylated (By similarity).
Ptm:	Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.
Disease:	Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11. 23.
Similarity:	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:	Contains 2 LIM zinc-binding domains.
Similarity:	Contains 1 PDZ (DHR) domain.
Similarity:	Contains 1 protein kinase domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/13/2025

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