TCEB1 (transcription elongation factor B (SIII). polypeptide 1 (15kDa. elongin C))

GWB-2E83BF

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. TCEB1 is known as protein elongin C. which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2. B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase a

The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits like VHL and members of the SOCS box family to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Nucleus (Probable).

Belongs to the SKP1 family. Summary: This protein is the protein elongin C which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2 B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation. Yu. X. . et al. . (2003) Science 302 (5647). 1056-1060.