Neuropeptide Y receptor type 5

3rd cytoplasmic domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (16 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Beauverger P. Rodriguez M. Nicolas J. P. Audinot V. Lamamy V. Dromaint S. Nagel N. Macia C. Leopold O. Galizzi J. P. et al. Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay[2] Rodriguez M. Audinot V. Dromaint S. Macia C. Lamamy V. Beauverger P. Rique H. Imbert J. Nicolas J. P. Boutin J. A. and et al. Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform[3] Parker E. Van Heek M. and Stamford A. et al. Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status[4] Nichol K. A. Morey A. Couzens M. H. Shine J. Herzog H. and Cunningham A. M. Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control[5] Lutz C. M. Richards J. E. Scott K. L. Sinha S. Yang-Feng T. L. Frankel W. N. and Thompson D. A. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY[6] Gerald C. Walker M. W. Criscione L. Gustafson E. L. Batzl-Hartmann C. Smith K. E. Vaysse P. Durkin M. M. Laz T. M. Linemeyer D. L. et al. A receptor subtype involved in neuropeptide-Y-induced food intake. [7] Hu Y. Bloomquist B. T. Cornfield L. J. Decarr L. B. Flores-Riveros J. R. Friedman L. Jiang P. Lewis-Higgins L. Sadlowski Y. Schaefer J. et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. [8] Herzog H. Darby K. Ball H. Hort Y. Beck-Sickinger A. Shine J. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. [9] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org).