RECOMBINANT HUMAN LEPTIN

GWB-F9CD71

Purified recombinant leptin expressed in E. coli.

Leptin is a major adipose-derived hormone and member of the leptin family which plays a key role in appetite control and the regulation of energy expenditure. Secreted leptin associates with proteins within the bloodstream and is transported to the brain where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity with a correlation between circulating levels of leptin and body fat mass and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin cortisol cAMP and thiazolidinediones.