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Human Collagen Type I

Human Collagen Type I

Item no.	11-511-248456
Manufacturer	GENWAY
Amount	0,5 mg
Category	Oncology Peptides & Proteins Recombinant Proteins Cell Biology ELISA Cell Stainings ECM By Organ Skin Cancer
Type	Proteins
Applications	ELISA
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-2F3160
Similar products	11-511-248456
Available
Genway ID:	GWB-2F3160
Specificity:	Collagen Type I Human
Type of Product:	Purified Collagens
Inactivation:	Pepsin digestion and storage in 500mM acetic acid
Buffer:	500mM Acetic acid
Preservative:	NoneApplications Notes : Type I collagen standard. Antigen for antibody production. Coating material for cell culture studies. Formation of collagen gels. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Concentration:	Concentration is lot specific Human Collagen Type I. Purified Human Collagen Type I
Function:	Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subunit:	Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity).
Subcellular Location:	Secreted extracellular space extracellular matrix (By similarity).
Tissue Specificity:	Forms the fibrils of tendon ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Ptm:	Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Ptm:	O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Disease:	Defects in COL1A1 are the cause of Caffey disease [MIM:114000]; also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones mandible and clavicles. The involved bones may also appear inflamed with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age.
Disease:	Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.
Disease:	Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A) [MIM:130060]; also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation hyperlaxity of the joints and recurrent partial dislocations.
Disease:	Defects in COL1A1 are a cause of osteogenesis imperfecta type I (OI-I) [MIM:166200]. OI-I is a dominantly inherited serious newborn disease characterized by bone fragility normal stature little or no deformity blue sclerae and hearing loss in 50% of families. Dentinogenesis imperfecta is rare and may distinguish a subset of OI type I (formation of dentine).
Disease:	Defects in COL1A1 are a cause of osteogenesis imperfecta type II (OI-II) [MIM:166210]; also known as osteogenesis imperfecta congenita. OI-II is lethal in the perinatal period and is charaterized by calvarial mineralization beaded ribs compressed femurs marked long bone deformity and platyspondyly (congenital flattening of the vertebral bodies).
Disease:	Defects in COL1A1 are a cause of osteogenesis imperfecta type III (OI-III) [MIM:259420]; also called progressively deforming osteogenesis imperfecta with normal sclerae. OI-III is characterized by progressively deforming bones usually with moderate deformity at birth sclerae is variable in color dentinogenesis imperfecta and hearing loss are common. The stature is very short.
Disease:	Defects in COL1A1 are a cause of osteogenesis imperfecta type IV (OI-IV) [MIM:166220]. OI-IV is charaterized by normal sclerae moderate to mild deformity and variable short stature. Dentinogenesis imperfecta is common and hearing loss occurs in some patients.
Disease:	Genetic variations in COL1A1 are associated with susceptibility to involutional osteoporosis [MIM:166710]; also known as senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mineral density disrutption of bone microarchitecture and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
Disease:	A chromosomal aberration involving COL1A1 is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17; 22)(q22; q13) with PDGF. DFSP is an uncommon locally aggressive but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.
Similarity:	Belongs to the fibrillar collagen family.
Similarity:	Contains 1 VWFC domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,5 mg

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