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Human Neutrophil Elastase

Human Neutrophil Elastase

Item no.	11-511-248569
Manufacturer	GENWAY
Amount	1000units
Category	Oncology Peptides & Proteins Recombinant Proteins Cardiovascular Research Atherosclerosis By Organ Bone Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-6C3C91
Similar products	11-511-248569
Available
Genway ID:	GWB-6C3C91
Specificity:	Elastase
Type of Product:	Purified Enzymes
Inactivation:	Not applicable
Buffer:	NoneApplications Notes : Specific methodologies have not been tested using this product.
Preservative:	None
Warning:	Prepared from whole blood shown to be nonreactive for HBsAg. anti-HCV. anti-HBc. and negative for anti-HIV 1 & 2 by FDA licensed tests. No test guarantees a product to be non-infectious. Therefore. all material derived from human fluids or tissues should be considered as potentially infectious.
Concentration:	Activity: 20 -22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of MeO-Suc-Ala-Ala-Pro-Val-pNA per minute at 25C in 100mM Tris-HCl pH 7. 5 with 500mM NaCl. Human Neutrophil Elastase
Function:	Modifies the functions of natural killer cells monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Catalytic Activity:	Hydrolysis of proteins including elastin. Preferential cleavage: Val-\|-Xaa & gt; Ala-\|-Xaa.
Subunit:	Interacts with NOTCH2NL.
Tissue Specificity:	Bone marrow cells.
Disease:	Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia affected individuals are at risk for opportunistic infection. Monocytes platelets lymphocytes and reticulocytes also cycle with the same frequency.
Disease:	Defects in ELA2 are the cause of autosomal dominant severe congenital neutropenia type 1 (SCN1) [MIM:202700]. Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0. 5 x 10(9)/l and early onset of severe bacterial infections.
Similarity:	Belongs to the peptidase S1 family. Elastase subfamily [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1000units

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Delivery expected until 9/11/2025

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