LYVE-1

aa 243-323

On SDS-PAGE commassie blue stained gel the purified recombinant protein shows a band at 36kDa. The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker LYVE-1 the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis and continues to be used for the detection and isolation of lymphatic endothelial cells. However LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumor metastasis LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumours exploit lymphatic vessels for metastasis.