Glucagon

Full length

On SDS-PAGE commassie blue stained gel the purified recombinant protein shows a band at 37 kDa (Including GST). Glucagon exerts rapid and delayed effects on the liver whereby it provokes a coordinated cAMP and Ca2+-dependent increase in glycogenolysis glycolysis glucose cycling gluconeogenesis and ketogenesis. Glucagon also stimulates hepatic proteolysis in lysosomes and inhibits protein synthesis so that glucogenic amino acids contribute easily to gluconeogenesis. Glucagon is found in other normal tissues such as small intestine and stomach.